diff --git a/ui-ngx/src/app/modules/home/components/widget/lib/gateway/gateway-service-rpc-connector.component.ts b/ui-ngx/src/app/modules/home/components/widget/lib/gateway/gateway-service-rpc-connector.component.ts
index 9838fd2df2..4b21b192d6 100644
--- a/ui-ngx/src/app/modules/home/components/widget/lib/gateway/gateway-service-rpc-connector.component.ts
+++ b/ui-ngx/src/app/modules/home/components/widget/lib/gateway/gateway-service-rpc-connector.component.ts
@@ -14,7 +14,7 @@
 /// limitations under the License.
 ///
 
-import { Component, EventEmitter, forwardRef, Input, OnInit, Output } from '@angular/core';
+import { Component, EventEmitter, forwardRef, Input, OnDestroy, OnInit, Output } from '@angular/core';
 import {
   ControlValueAccessor,
   FormArray,
@@ -53,6 +53,8 @@ import {
 } from '@shared/components/dialog/json-object-edit-dialog.component';
 import { jsonRequired } from '@shared/components/json-object-edit.component';
 import { deepClone } from '@core/utils';
+import { takeUntil, tap } from "rxjs/operators";
+import { Subject } from "rxjs";
 
 @Component({
   selector: 'tb-gateway-service-rpc-connector',
@@ -66,7 +68,7 @@ import { deepClone } from '@core/utils';
     }
   ]
 })
-export class GatewayServiceRPCConnectorComponent implements OnInit, ControlValueAccessor {
+export class GatewayServiceRPCConnectorComponent implements OnInit, OnDestroy, ControlValueAccessor {
 
   @Input()
   connectorType: ConnectorType;
@@ -105,6 +107,7 @@ export class GatewayServiceRPCConnectorComponent implements OnInit, ControlValue
 
   private propagateChange = (v: any) => {
   }
+  private destroy$ = new Subject<void>();
 
   constructor(private fb: FormBuilder,
               private dialog: MatDialog,) {
@@ -138,6 +141,12 @@ export class GatewayServiceRPCConnectorComponent implements OnInit, ControlValue
       }
     });
     this.isMQTTWithResponse = this.fb.control(false);
+    this.observeMQTTWithResponse();
+  }
+
+  ngOnDestroy(): void {
+    this.destroy$.next();
+    this.destroy$.complete();
   }
 
   connectorParamsFormGroupByType(type: ConnectorType): FormGroup {
@@ -148,7 +157,7 @@ export class GatewayServiceRPCConnectorComponent implements OnInit, ControlValue
         formGroup = this.fb.group({
           methodFilter: [null, [Validators.required, Validators.pattern(noLeadTrailSpacesRegex)]],
           requestTopicExpression: [null, [Validators.required, Validators.pattern(noLeadTrailSpacesRegex)]],
-          responseTopicExpression: [null, [Validators.pattern(noLeadTrailSpacesRegex)]],
+          responseTopicExpression: [{ value: null, disabled: true }, [Validators.required, Validators.pattern(noLeadTrailSpacesRegex)]],
           responseTimeout: [null, [Validators.min(10), Validators.pattern(this.numbersOnlyPattern)]],
           valueExpression: [null, [Validators.required, Validators.pattern(noLeadTrailSpacesRegex)]],
         })
@@ -424,4 +433,14 @@ export class GatewayServiceRPCConnectorComponent implements OnInit, ControlValue
       this.commandForm.patchValue(value, {onlySelf: false});
     }
   }
+
+  private observeMQTTWithResponse(): void {
+    this.isMQTTWithResponse.valueChanges.pipe(
+      tap((isActive: boolean) => {
+        const responseControl = this.commandForm.get('responseTopicExpression');
+        isActive ? responseControl.enable() : responseControl.disable();
+      }),
+      takeUntil(this.destroy$),
+    ).subscribe();
+  }
 }